UCP Journal of Science & Technology http://ojs.ucp.edu.pk/index.php/ucpjst <p>UCP Journal of Science and Technology (UCP-JST) is a multidisciplinary, peer-reviewed, and open-access journal published by the Faculty of Science and Technology, University of Central Punjab (UCP), devoted to publishing research in the field of Science and Technology. Emphasizing original intellectual work with scholarly insight, the UCP Journal of Sciences and Technology aims to publish high-quality articles in the fields of biological, physical, natural, and life sciences.</p> <p><strong>ISSN Numbers:</strong> 3005-5571 (Online), 3005-5563 (Print)</p> en-US editorinchief.jst@ucp.edu.pk (Dr. Hafiza Rizwana Kausar) jstme@ucp.edu.pk (Dr. Nimra Afzal) Mon, 25 Sep 2023 00:00:00 +0000 OJS http://blogs.law.harvard.edu/tech/rss 60 Acinetobacter as Model Organism: Environmental and Biotechnological Applications http://ojs.ucp.edu.pk/index.php/ucpjst/article/view/36 <p>Among different microbial groups present in nature, Acinetobacter holds an important place because of its profuse presence in varied environments like freshwater, soil, solid wastes and wastewater. Versatile metabolic characteristics of different species of genus Acinetobacter have been fascinating emergent interest in different fields of environmental, medical, and biotechnological perspective. Various members of this genus are recognized to be involved in biodegradation, treatment and removal of various inorganic and organic hazardous wastes. Some Acinetobacter strains are also well-characterized to produce industrially valuable bioproducts. Because of its ecological importance, genus Acinetobacter also considered as model organism for environmental and industrial microbiological studies. This review recapitulates the practicality and various applications of Acinetobacter strains in the environmental and in the field&nbsp; of biotechnology.&nbsp;</p> <p>Key words: Acinetobacter, biodegradation, bioemulsans, Biosurfactant, &nbsp;polysaccharides.</p> Iqra Jamil, Farhan Rasheed Copyright (c) 2023 UCP Journal of Science & Technology https://creativecommons.org/licenses/by-nc/4.0 http://ojs.ucp.edu.pk/index.php/ucpjst/article/view/36 Mon, 25 Sep 2023 00:00:00 +0000 Effect of Carrot-Beet Based Beverages to Modulate Hypertension http://ojs.ucp.edu.pk/index.php/ucpjst/article/view/38 <p><strong>Background and aims: </strong>The objective of this study was to assess the effect of carrot and beetroot-based beverages to modulate hypertension in hypertensive subjects.</p> <p><strong>Methods:</strong> Two different combinations of carrot beetroot juice were prepared consisting of Beverage-I (carrot juice 20% and beetroot juice 80%) and Beverage-II (carrot juice 40%, beetroot juice 60%). Antihypertensive influence of beverages was assessed through physiological markers <em>i.e.</em> pulse rate, body temperature, systolic and diastolic blood pressure. Serum lipid profile including triglycerides, cholesterol, high density lipoprotein and low-density lipoprotein was also at start and at termination of the experimental trial.</p> <p><strong>Results:</strong> Results obtained at the end of study revealed that Beverage-I influentially reduced the pulse rate, systolic and diastolic pressure, triglycerides and LDL levels however, in case of total cholesterol, more pronounced effect was observed in subjects receiving Beverage II.</p> <p><strong>Conclusions:</strong> From the outcomes, it was concluded that both of these beverages showed modulation of hypertension and hence, these beverages can be employed in routine dietary therapy.</p> Poushmal Abdul Razzaq, Masood Sadiq Butt, Iahtisham-Ul Haq, Urwa Tariq Copyright (c) 2023 UCP Journal of Science & Technology https://creativecommons.org/licenses/by-nc/4.0 http://ojs.ucp.edu.pk/index.php/ucpjst/article/view/38 Mon, 25 Sep 2023 00:00:00 +0000 IL-17: New Insights into Advances from diagnostics to therapeutics of inflammatory diseases http://ojs.ucp.edu.pk/index.php/ucpjst/article/view/72 <p>Interleukin 17 (IL-17) is a proinflammatory cytokine having 6 related cytokines. Over the past few years, the roles of IL-17 go beyond not merely activating inflammation but also progression of disease. Evidence is mounting that IL-17 has significant roles in causing and developing various inflammatory diseases. And recently, specific inhibitions of IL-17 have improved in the treatment of these diseases. This review aims to highlight the general trends of these treatments as well as the various diseases related to IL-17 inflammatory actions, and interactions with other cytokines that perform similar functions.</p> Ume Habiba, Muhammad Babar Khawar, Abdullah Muhammad Sohail, Ali Afzal, Muddasir Hassan Abbasi, Nadeem Sheikh, Muhammad Ahsan Ashraf, Syeda Eisha Hamid, Sara Shahzaman Copyright (c) 2023 UCP Journal of Science & Technology https://creativecommons.org/licenses/by-nc/4.0 http://ojs.ucp.edu.pk/index.php/ucpjst/article/view/72 Mon, 25 Sep 2023 00:00:00 +0000 Computational Design and Analysis of a Novel Inhibitor for FERMT1 Gene: A Novel Treatment Strategy for the Kindler Syndrome http://ojs.ucp.edu.pk/index.php/ucpjst/article/view/74 <p>Epidermolysis Bullosa (EB) is a rare genetic condition characterized by skin blistering that occurs with minimal trauma such as scratching or rubbing. EB is a polygenic disorder caused by various genes, each responsible for different subtypes. This study focuses on Kindler Syndrome, which is caused by mutations in the FERMT1 (FERM Domain Containing Kindlin 1) gene. Currently, topical medications are the primary treatment options due to the lack of suitable drugs. To address this, a computer-aided drug has been designed that could potentially act as an inhibitor for treating Kindler Syndrome. The FERM1 HUMAN protein of FERMT1 was retrieved from the UNIPROT database (with the UNIPROT ID of Q9BQL6) and its secondary and tertiary structure were analyzed using MESSA and AlphaFold 2, respectively. A ligand was then constructed using the Elea3D drug design server and the best ligand, based on the maximum population score, was used to predict and analyze its interaction with the FERMT1 protein using SwissDock. The complex obtained was further subjected to molecular dynamics simulation using IMODs. Finally, ADMET analysis was performed to evaluate the drug-likeness, toxicity, water solubility, and physiochemical properties of the designed drug. Computer-aided drug designed in this study holds potential for treating Kindler Syndrome and may yield exceptional results in in vivo and in vitro studies. Overall, this study demonstrates the potential for using computer-aided drug design to develop new treatments for rare genetic disorders like Kindler Syndrome.</p> Muhammad Aqib Shabbir, Mah Hoor Javed, Aqsa Waqar, Hafiz Muhammad Hurraira Copyright (c) 2023 UCP Journal of Science & Technology https://creativecommons.org/licenses/by-nc/4.0 http://ojs.ucp.edu.pk/index.php/ucpjst/article/view/74 Mon, 25 Sep 2023 00:00:00 +0000 Design concept of cost effective LEO satellite system for Automatic Dependent Surveillance-Broadcast (ADS-B) http://ojs.ucp.edu.pk/index.php/ucpjst/article/view/79 <p style="text-indent: 0in; margin-bottom: 0in;">Primary technique being used for air traffic surveillance is radar. But now-a-days its capacity surveillance is gradually being replaced by newly used Automatic Dependent Surveillance–Broadcast (ADS-B). ADS-B offers higher accuracy, low power consumption and long range than radar, which provides more safety to aircrafts. The coverage of terrestrial radar and ADS-B is confined to continental parts of the globe, leaving oceans and poles uncovered by real-time surveillance measures. On the other hand air traffic is growing rapidly, making available airspace more and more congested. The paper presents the design of a space based ADS-B system of 20 satellites for global air traffic surveillance over intercontinental trans-oceanic flight routes to make better use of available airspace. Performance assessment of the designed constellation is based on the analysis of various parameters such as regional and global coverage and satellite availability. LEO satellite handover mechanism and link budget for ADS-B system are also discussed. The results of parametric analysis indicate that the constellation provides adequate coverage in the simulated global and regional areas. The constellation is a feasible and cost effective solution for global air surveillance which can supplement/replace the terrestrial ADS-B and radar systems.</p> Ghulam Jaffer, Rameez Ahmed Malik Copyright (c) 2023 UCP Journal of Science & Technology https://creativecommons.org/licenses/by-nc/4.0 http://ojs.ucp.edu.pk/index.php/ucpjst/article/view/79 Mon, 25 Sep 2023 00:00:00 +0000